5years old dog presented for sudden appearance of single lump on the lateral abdominal wall, soon after another lump right next to it

• other than these two lumps , the case didn't show any abnormalities

• Fine-Needle Aspiration (FNA): was inconclusive because liposarcomas can mimic normal fat cytologically.
• CT: Useful to assess depth, invasion, also recommended to evaluate for pulmonary metastases.
• Histopathology: Required for definitive diagnosis and submitted after surgical excision

surgical excision of both lumps and submitted for histopathology
another lump appeared after 1 week between the shoulders

histologically mass was confirmed to be Liposarcoma

1. Doxorubicin-Based Protocols

• Dose: 30 mg/m² IV every 3 weeks for 4–6 cycles
• Mechanism: Anthracycline antibiotic; interferes with DNA replication and causes apoptosis in rapidly dividing cells.
• Notes:
  • Most effective agent reported for soft tissue sarcomas, including liposarcomas.
  • Monitor for cardiotoxicity, myelosuppression, and gastrointestinal side effects.